Bears moved price down into 57 to 54 cents support zone. Price is now very close to the 200 days EMA support line and the 54 cents immediate support line. Retest of major long term uptrend support line will occur if the bears manage to break 54 cents support.
Big Bears selling during late morning and early afternoon trading.
Small bulls buying before closing.
If no Big Bull appears tomorrow 54 cents support will be broken.
What is it? What does it do?
The International Centre for Genetic Engineering and Biotechnology conducts innovative research in life sciences for the benefit of developing countries. It strengthens the research capability of its Members through training and funding programmes and advisory services and represents a comprehensive approach to promoting biotechnology internationally. The Centre is dedicated to advanced research and training in molecular biology and biotechnology and holds out the prospect of advancing knowledge and applying the latest techniques in the fields of:biomedicine; crop improvement; environmental protection/remediation; biopharmaceuticals and biopestidice production.
ICGEB provides a scientific and educational environment of the highest standard. It brings biotechnology to developing countries by strengthening their research capabilities, developing state-of-the-art research and training scientists to the benefit of its Member States.
Located in Trieste, Italy, New Delhi, India and Cape Town, South Africa, the Centre forms an interactive network with Affiliated Centres in ICGEB Member States.
http://www.icgeb.trieste.it/GENERAL/centrint.htm
Although they are tiny, microRNAs can have large-scale effects because they regulate a variety of genes. These minuscule molecules are now definitively linked to the development of cancer.
During the past few years, molecular biologists have been stunned by the discovery of hundreds of genes that encode small RNA molecules1. These microRNAs (miRNAs) — 21 to 25 nucleotides in length — are negative regulators of gene expression. The mechanisms by which they work are similar in plants and animals, implying that they are involved in fundamental cellular processes2. As cancer is essentially a consequence of disordered genome function, one might expect these regulatory molecules to be involved in the development of this disease. Indeed, there are hints that the levels of some miRNAs are altered in cancer3, 4; there is also evidence that an miRNA regulates the cancer-promoting ras gene5. Three studies in this issue6, 7, 8 change the landscape of cancer genetics by establishing the specific miRNAs expressed in most common cancers, and investigating the effects of miRNAs on cancer development and cancer genes.
The initial product of an miRNA gene (Fig. 1) goes through several processing steps before it is exported from the nucleus to the cytoplasm. One strand of the resulting double-stranded RNA is then incorporated into the 'RNA-induced silencing complex' (RISC). RISC can target protein-coding messenger RNAs (mRNAs) either for inhibition, by blocking their translation into protein, or destruction (as in RNA interference). Base pairing between the miRNA and its complementary target mRNA gives the process its specificity.
http://www.nature.com/nature/journal/v435/n7043/full/435745a.html
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently believed that four to six crypt stem cells reside at the +4 position immediately above the Paneth cells in the small intestine; colon stem cells remain undefined. Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5, also known as Gpr49) was selected from a panel of intestinal Wnt target genes for its restricted crypt expression. Here, using two knock-in alleles, we reveal exclusive expression of Lgr5 in cycling columnar cells at the crypt base. In addition, Lgr5 was expressed in rare cells in several other tissues. Using an inducible Cre knock-in allele and the Rosa26-lacZ reporter strain, lineage-tracing experiments were performed in adult mice. The Lgr5-positive crypt base columnar cell generated all epithelial lineages over a 60-day period, suggesting that it represents the stem cell of the small intestine and colon. The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers.
http://www.nature.com/nature/journal/v449/n7165/abs/nature06196.html
