China Hongx Testing Downtrend Line

Interesting day tomorrow if buying momentum continues. Breakout from red downtrend resistance line will retest previous peak at 74 cents. Breakdown from blue uptrend line will retest 58 cents support. Monitor 20 EMA resistance line.

Enterprise application integration

Enterprise Application Integration (EAI) is defined as the uses of software and computer systems architectural principles to integrate a set of enterprise computer applications.

Many medium-size and large corporations use a variety of computer applications for managing data, including supply chain management applications (for managing inventory and shipping), customer relationship management applications (for managing current and potential customers), business intelligence applications (for managing internal operations), and other types of applications (for managing data such as human resources data, internal communications, etc). Unfortunately, such applications typically cannot communicate with one another in order to share data or business rules; for this reason, such applications are sometimes referred to as islands of automation or information silos. This lack of communication leads to inefficiency, in the form of the same data having to be stored in multiple locations, or straightforward processes that are unable to be automated.

Enterprise application integration (EAI) is the process of linking such applications within a single organization together in order to simplify and automate business processes to the greatest extent possible, while at the same time avoiding having to make sweeping changes to the existing applications or data structures. In the words of the Gartner Group, EAI is the “unrestricted sharing of data and business processes among any connected application or data sources in the enterprise.”[1]

One large challenge of EAI is that the various systems that need to be linked together often reside on different operating systems, use different database solutions and different computer languages, and in some cases are legacy systems that are no longer supported by the vendor who originally created them. In some cases, such systems are dubbed "stovepipe systems" because they consist of components that have been jammed together in a way that makes it very hard to modify them in any way.

http://en.wikipedia.org/wiki/Enterprise_application_integration

Computer Model Identifies Membrane Contact Areas of Proteins

Researchers at the San Diego Supercomputer Center and UC San Diego developed a new tool called MAPAS (membrane-associated protein assessments) to study how proteins contact cell membranes.

The traditional method of studying proteins has difficulty in identifying the key parts of a protein that will participate in membrane contact, report the investigators. “It’s extremely important to explore the structural details of the zone where the protein contacts the membrane so that we can understand the molecular mechanisms of disease development,” notes Igor F Tsigelny at UCSD. “This knowledge gives crucial guidance in selecting which among many possible compounds are most likely to do well in tests to intervene in such protein-membrane interactions and help treat these diseases.”

The MAPAS tool, the researchers explain, takes as a starting point a protein’s known 3-D shape and then applies a set of scoring methods based on comprehensive steered molecular dynamics calculations to predict whether this protein structure can form strong contacts with the cell membrane.

If so, MAPAS goes on to identify all the flat faces or planes that make up this protein, they add. It is these planar protein surfaces that can attach to the cell membrane. MAPAS predicts which of these regions are most likely to bind to the membrane based on specific protein contacts with the lipids or fats that make up the membrane, according to the scientists.

The team validated the performance of MAPAS by confirming that it correctly models a number of membrane-contacting proteins that are already known.

http://www.genengnews.com/news/bnitem.aspx?name=29733938

microRNAs

The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

MicroRNAs (miRNAs) are single-stranded, noncoding RNAs that are important in many biological processes1, 2. Although the oncogenic and tumour-suppressive functions of several miRNAs have been characterized, the role of miRNAs in mediating tumour metastasis was addressed only recently3 and still remains largely unexplored4, 5. To identify potential metastasis-promoting miRNAs, we set up a genetic screen using a non-metastatic, human breast tumour cell line that was transduced with a miRNA-expression library and subjected to a trans-well migration assay. We found that human miR-373 and miR-520c stimulated cancer cell migration and invasion in vitro and in vivo, and that certain cancer cell lines depend on endogenous miR-373 activity to migrate efficiently. Mechanistically, the migration phenotype of miR-373 and miR-520c can be explained by suppression of CD44. We found significant upregulation of miR-373 in clinical breast cancer metastasis samples that correlated inversely with CD44 expression. Taken together, our findings indicate that miRNAs are involved in tumour migration and invasion, and implicate miR-373 and miR-520c as metastasis-promoting miRNAs.

http://www.nature.com/ncb/journal/v10/n2/abs/ncb1681.html

Yangzijiang 30 mins chart $1.30 resistance turned support must be defended

Bulls regain critical higher ground and the $1.32 to $1.30 resistance zone has been transformed into the new support zone. Bulls must retain this higher ground to ensure price momentum remains strong. New immediate resistance is now $1.36 to $1.39. Monitor 20 EMA, 50 EMA and 200 EMA resistance and support lines.

Capitaland 10 mins chart 4 Feb 2008 958 AM

Gapped up on opening to create an intraday high at $5.95. Immediate resistance zone is now at $5.95 to $6.02. Breakout above this resistance zone will propel price towards downtrend resistance line. Immediate support is $5.80. Monitor 20 EMA, 50 EMA and 200 EMA support and resistance lines.